| Milwaukee Brewers at Houston Astros Fri, 05/29/2026 7:10 PM CDT | Fri, 05/29/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Milwaukee Brewers at Houston Astros Sat, 05/30/2026 3:10 PM CDT | Sat, 05/30/2026 3:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Milwaukee Brewers at Houston Astros Sun, 05/31/2026 1:10 PM CDT | Sun, 05/31/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Pittsburgh Pirates at Houston Astros Tue, 06/02/2026 7:10 PM CDT | Tue, 06/02/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Pittsburgh Pirates at Houston Astros Wed, 06/03/2026 7:10 PM CDT | Wed, 06/03/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Pittsburgh Pirates at Houston Astros Thu, 06/04/2026 7:10 PM CDT | Thu, 06/04/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Athletics at Houston Astros Fri, 06/05/2026 7:10 PM CDT | Fri, 06/05/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Athletics at Houston Astros Sat, 06/06/2026 3:10 PM CDT | Sat, 06/06/2026 3:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Athletics at Houston Astros Sun, 06/07/2026 1:10 PM CDT | Sun, 06/07/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Detroit Tigers at Houston Astros Mon, 06/15/2026 7:10 PM CDT | Mon, 06/15/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Detroit Tigers at Houston Astros Tue, 06/16/2026 7:10 PM CDT | Tue, 06/16/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Detroit Tigers at Houston Astros Wed, 06/17/2026 1:10 PM CDT | Wed, 06/17/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Cleveland Guardians at Houston Astros Fri, 06/19/2026 7:10 PM CDT | Fri, 06/19/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Cleveland Guardians at Houston Astros Sat, 06/20/2026 6:15 PM CDT | Sat, 06/20/2026 6:15 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Cleveland Guardians at Houston Astros Sun, 06/21/2026 1:10 PM CDT | Sun, 06/21/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Minnesota Twins at Houston Astros Mon, 06/29/2026 7:10 PM CDT | Mon, 06/29/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Minnesota Twins at Houston Astros Tue, 06/30/2026 7:10 PM CDT | Tue, 06/30/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Minnesota Twins at Houston Astros Wed, 07/01/2026 7:10 PM CDT | Wed, 07/01/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Tampa Bay Rays at Houston Astros Fri, 07/03/2026 7:10 PM CDT | Fri, 07/03/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Tampa Bay Rays at Houston Astros Sat, 07/04/2026 6:10 PM CDT | Sat, 07/04/2026 6:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Tampa Bay Rays at Houston Astros Sun, 07/05/2026 2:30 PM CDT | Sun, 07/05/2026 2:30 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Baltimore Orioles at Houston Astros Fri, 07/17/2026 7:10 PM CDT | Fri, 07/17/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Baltimore Orioles at Houston Astros Sat, 07/18/2026 3:10 PM CDT | Sat, 07/18/2026 3:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Baltimore Orioles at Houston Astros Sun, 07/19/2026 1:10 PM CDT | Sun, 07/19/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Miami Marlins at Houston Astros Mon, 07/20/2026 7:10 PM CDT | Mon, 07/20/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Miami Marlins at Houston Astros Tue, 07/21/2026 7:10 PM CDT | Tue, 07/21/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Miami Marlins at Houston Astros Wed, 07/22/2026 7:10 PM CDT | Wed, 07/22/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Texas Rangers at Houston Astros Fri, 07/31/2026 7:10 PM CDT | Fri, 07/31/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Texas Rangers at Houston Astros Sat, 08/01/2026 6:10 PM CDT | Sat, 08/01/2026 6:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Texas Rangers at Houston Astros Sun, 08/02/2026 1:10 PM CDT | Sun, 08/02/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Toronto Blue Jays at Houston Astros Mon, 08/03/2026 7:10 PM CDT | Mon, 08/03/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Toronto Blue Jays at Houston Astros Tue, 08/04/2026 7:10 PM CDT | Tue, 08/04/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Toronto Blue Jays at Houston Astros Wed, 08/05/2026 1:10 PM CDT | Wed, 08/05/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Seattle Mariners at Houston Astros Fri, 08/14/2026 7:10 PM CDT | Fri, 08/14/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Seattle Mariners at Houston Astros Sat, 08/15/2026 6:10 PM CDT | Sat, 08/15/2026 6:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Seattle Mariners at Houston Astros Sun, 08/16/2026 6:20 PM CDT | Sun, 08/16/2026 6:20 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Seattle Mariners at Houston Astros Sun, 08/16/2026 6:20 PM CDT | Sun, 08/16/2026 6:20 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Los Angeles Angels at Houston Astros Tue, 08/18/2026 7:10 PM CDT | Tue, 08/18/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Los Angeles Angels at Houston Astros Wed, 08/19/2026 7:10 PM CDT | Wed, 08/19/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Los Angeles Angels at Houston Astros Thu, 08/20/2026 7:10 PM CDT | Thu, 08/20/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Athletics at Houston Astros Fri, 08/21/2026 7:10 PM CDT | Fri, 08/21/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Athletics at Houston Astros Sat, 08/22/2026 6:10 PM CDT | Sat, 08/22/2026 6:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Athletics at Houston Astros Sun, 08/23/2026 1:10 PM CDT | Sun, 08/23/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Chicago White Sox at Houston Astros Mon, 08/31/2026 7:10 PM CDT | Mon, 08/31/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Chicago White Sox at Houston Astros Tue, 09/01/2026 7:10 PM CDT | Tue, 09/01/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Chicago White Sox at Houston Astros Wed, 09/02/2026 7:10 PM CDT | Wed, 09/02/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Chicago White Sox at Houston Astros Thu, 09/03/2026 1:10 PM CDT | Thu, 09/03/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Arizona Diamondbacks at Houston Astros Fri, 09/04/2026 7:10 PM CDT | Fri, 09/04/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Arizona Diamondbacks at Houston Astros Sat, 09/05/2026 6:15 PM CDT | Sat, 09/05/2026 6:15 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Arizona Diamondbacks at Houston Astros Sun, 09/06/2026 1:10 PM CDT | Sun, 09/06/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
