| Houston Astros at Chicago Cubs Fri, 05/22/2026 1:20 PM CDT | Fri, 05/22/2026 1:20 PM CDT | Chicago Cubs | Wrigley Field | Chicago | Flat | - |
| Houston Astros at Chicago Cubs Sat, 05/23/2026 1:20 PM CDT | Sat, 05/23/2026 1:20 PM CDT | Chicago Cubs | Wrigley Field | Chicago | Flat | - |
| Houston Astros at Chicago Cubs Sun, 05/24/2026 1:20 PM CDT | Sun, 05/24/2026 1:20 PM CDT | Chicago Cubs | Wrigley Field | Chicago | Flat | - |
| Houston Astros at Texas Rangers Mon, 05/25/2026 6:05 PM CDT | Mon, 05/25/2026 6:05 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
| Houston Astros at Texas Rangers Tue, 05/26/2026 7:05 PM CDT | Tue, 05/26/2026 7:05 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
| Houston Astros at Texas Rangers Wed, 05/27/2026 7:05 PM CDT | Wed, 05/27/2026 7:05 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
| Houston Astros at Texas Rangers Thu, 05/28/2026 7:05 PM CDT | Thu, 05/28/2026 7:05 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
| Milwaukee Brewers at Houston Astros Fri, 05/29/2026 7:10 PM CDT | Fri, 05/29/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Milwaukee Brewers at Houston Astros Sat, 05/30/2026 3:10 PM CDT | Sat, 05/30/2026 3:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Milwaukee Brewers at Houston Astros Sun, 05/31/2026 1:10 PM CDT | Sun, 05/31/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Pittsburgh Pirates at Houston Astros Tue, 06/02/2026 7:10 PM CDT | Tue, 06/02/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Pittsburgh Pirates at Houston Astros Wed, 06/03/2026 7:10 PM CDT | Wed, 06/03/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Pittsburgh Pirates at Houston Astros Thu, 06/04/2026 7:10 PM CDT | Thu, 06/04/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Athletics at Houston Astros Fri, 06/05/2026 7:10 PM CDT | Fri, 06/05/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Athletics at Houston Astros Sat, 06/06/2026 3:10 PM CDT | Sat, 06/06/2026 3:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Athletics at Houston Astros Sun, 06/07/2026 1:10 PM CDT | Sun, 06/07/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Houston Astros at Los Angeles Angels Mon, 06/08/2026 6:38 PM PDT | Mon, 06/08/2026 6:38 PM PDT | Los Angeles Angels | Angel Stadium of Anaheim | Anaheim | Flat | - |
| Houston Astros at Los Angeles Angels Tue, 06/09/2026 6:38 PM PDT | Tue, 06/09/2026 6:38 PM PDT | Los Angeles Angels | Angel Stadium of Anaheim | Anaheim | Flat | - |
| Houston Astros at Los Angeles Angels Wed, 06/10/2026 6:38 PM PDT | Wed, 06/10/2026 6:38 PM PDT | Los Angeles Angels | Angel Stadium of Anaheim | Anaheim | Flat | - |
| Houston Astros at Kansas City Royals Fri, 06/12/2026 7:10 PM CDT | Fri, 06/12/2026 7:10 PM CDT | Kansas City Royals | Kauffman Stadium | Kansas City | Flat | - |
| Houston Astros at Kansas City Royals Fri, 06/12/2026 7:10 PM CDT | Fri, 06/12/2026 7:10 PM CDT | Kansas City Royals | Kauffman Stadium | Kansas City | Flat | - |
| Houston Astros at Kansas City Royals Sat, 06/13/2026 6:15 PM CDT | Sat, 06/13/2026 6:15 PM CDT | Kansas City Royals | Kauffman Stadium | Kansas City | Flat | - |
| Houston Astros at Kansas City Royals Sun, 06/14/2026 1:10 PM CDT | Sun, 06/14/2026 1:10 PM CDT | Kansas City Royals | Kauffman Stadium | Kansas City | Flat | - |
| Detroit Tigers at Houston Astros Mon, 06/15/2026 7:10 PM CDT | Mon, 06/15/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Detroit Tigers at Houston Astros Tue, 06/16/2026 7:10 PM CDT | Tue, 06/16/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Detroit Tigers at Houston Astros Wed, 06/17/2026 1:10 PM CDT | Wed, 06/17/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Cleveland Guardians at Houston Astros Fri, 06/19/2026 7:10 PM CDT | Fri, 06/19/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Cleveland Guardians at Houston Astros Sat, 06/20/2026 6:15 PM CDT | Sat, 06/20/2026 6:15 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Cleveland Guardians at Houston Astros Sun, 06/21/2026 1:10 PM CDT | Sun, 06/21/2026 1:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Houston Astros at Toronto Blue Jays Mon, 06/22/2026 7:07 PM EDT | Mon, 06/22/2026 7:07 PM EDT | Toronto Blue Jays | Rogers Centre | Toronto | Flat | - |
| Houston Astros at Toronto Blue Jays Mon, 06/22/2026 7:07 PM EDT | Mon, 06/22/2026 7:07 PM EDT | Toronto Blue Jays | Rogers Centre | Toronto | Flat | - |
| Houston Astros at Toronto Blue Jays Tue, 06/23/2026 4:07 PM EDT | Tue, 06/23/2026 4:07 PM EDT | Toronto Blue Jays | Rogers Centre | Toronto | Flat | - |
| Houston Astros at Toronto Blue Jays Tue, 06/23/2026 7:07 PM EDT | Tue, 06/23/2026 7:07 PM EDT | Toronto Blue Jays | Rogers Centre | Toronto | Flat | - |
| Houston Astros at Toronto Blue Jays Wed, 06/24/2026 7:07 PM EDT | Wed, 06/24/2026 7:07 PM EDT | Toronto Blue Jays | Rogers Centre | Toronto | Flat | - |
| Houston Astros at Toronto Blue Jays Wed, 06/24/2026 7:07 PM EDT | Wed, 06/24/2026 7:07 PM EDT | Toronto Blue Jays | Rogers Centre | Toronto | Flat | - |
| Houston Astros at Detroit Tigers Thu, 06/25/2026 5:40 PM EDT | Thu, 06/25/2026 5:40 PM EDT | Detroit Tigers | Comerica Park | Detroit | Flat | - |
| Houston Astros at Detroit Tigers Fri, 06/26/2026 5:40 PM EDT | Fri, 06/26/2026 5:40 PM EDT | Detroit Tigers | Comerica Park | Detroit | Flat | - |
| Houston Astros at Detroit Tigers Sat, 06/27/2026 12:10 PM EDT | Sat, 06/27/2026 12:10 PM EDT | Detroit Tigers | Comerica Park | Detroit | Flat | - |
| Houston Astros at Detroit Tigers Sun, 06/28/2026 12:40 PM EDT | Sun, 06/28/2026 12:40 PM EDT | Detroit Tigers | Comerica Park | Detroit | Flat | - |
| Minnesota Twins at Houston Astros Mon, 06/29/2026 7:10 PM CDT | Mon, 06/29/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Minnesota Twins at Houston Astros Tue, 06/30/2026 7:10 PM CDT | Tue, 06/30/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Minnesota Twins at Houston Astros Wed, 07/01/2026 7:10 PM CDT | Wed, 07/01/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Tampa Bay Rays at Houston Astros Fri, 07/03/2026 7:10 PM CDT | Fri, 07/03/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Tampa Bay Rays at Houston Astros Sat, 07/04/2026 6:10 PM CDT | Sat, 07/04/2026 6:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Tampa Bay Rays at Houston Astros Sun, 07/05/2026 2:30 PM CDT | Sun, 07/05/2026 2:30 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
| Houston Astros at Washington Nationals Mon, 07/06/2026 7:05 PM EDT | Mon, 07/06/2026 7:05 PM EDT | Washington Nationals | Nationals Park | Washington | Flat | - |
| Houston Astros at Washington Nationals Tue, 07/07/2026 6:45 PM EDT | Tue, 07/07/2026 6:45 PM EDT | Washington Nationals | Nationals Park | Washington | Flat | - |
| Houston Astros at Washington Nationals Wed, 07/08/2026 6:45 PM EDT | Wed, 07/08/2026 6:45 PM EDT | Washington Nationals | Nationals Park | Washington | Flat | - |
| Houston Astros at Texas Rangers Fri, 07/10/2026 7:05 PM CDT | Fri, 07/10/2026 7:05 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
| Houston Astros at Texas Rangers Sat, 07/11/2026 6:05 PM CDT | Sat, 07/11/2026 6:05 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
