| NHL Preseason - Columbus Blue Jackets at Buffalo Sabres Tue, 09/22/2026 7:00 PM EDT | Tue, 09/22/2026 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| NHL Preseason - Pittsburgh Penguins at Buffalo Sabres Sat, 09/26/2026 3:00 PM EDT | Sat, 09/26/2026 3:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Chicago Blackhawks at Buffalo Sabres (Home Opener) Sat, 10/03/2026 7:00 PM EDT | Sat, 10/03/2026 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Chicago Blackhawks at Buffalo Sabres Sat, 10/03/2026 7:00 PM EDT | Sat, 10/03/2026 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Minnesota Wild at Buffalo Sabres Tue, 10/06/2026 8:00 PM EDT | Tue, 10/06/2026 8:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Dallas Stars at Buffalo Sabres Thu, 10/08/2026 7:00 PM EDT | Thu, 10/08/2026 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Utah Mammoth at Buffalo Sabres Sat, 10/10/2026 7:00 PM EDT | Sat, 10/10/2026 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Florida Panthers at Buffalo Sabres Mon, 10/12/2026 1:00 PM EDT | Mon, 10/12/2026 1:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Philadelphia Flyers at Buffalo Sabres Wed, 10/21/2026 7:30 PM EDT | Wed, 10/21/2026 7:30 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Ottawa Senators at Buffalo Sabres Wed, 11/04/2026 7:30 PM EST | Wed, 11/04/2026 7:30 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Columbus Blue Jackets at Buffalo Sabres Fri, 11/06/2026 7:00 PM EST | Fri, 11/06/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Vegas Golden Knights at Buffalo Sabres Sun, 11/08/2026 3:30 PM EST | Sun, 11/08/2026 3:30 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Tampa Bay Lightning at Buffalo Sabres Wed, 11/11/2026 7:30 PM EST | Wed, 11/11/2026 7:30 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| New York Rangers at Buffalo Sabres Wed, 11/25/2026 7:00 PM EST | Wed, 11/25/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Pittsburgh Penguins at Buffalo Sabres Fri, 11/27/2026 8:00 PM EST | Fri, 11/27/2026 8:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Edmonton Oilers at Buffalo Sabres Thu, 12/10/2026 7:00 PM EST | Thu, 12/10/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Anaheim Ducks at Buffalo Sabres Sat, 12/12/2026 7:00 PM EST | Sat, 12/12/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Calgary Flames at Buffalo Sabres Tue, 12/15/2026 7:00 PM EST | Tue, 12/15/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Montreal Canadiens at Buffalo Sabres Fri, 12/18/2026 7:00 PM EST | Fri, 12/18/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Los Angeles Kings at Buffalo Sabres Sun, 12/20/2026 6:00 PM EST | Sun, 12/20/2026 6:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| New Jersey Devils at Buffalo Sabres Sat, 12/26/2026 7:00 PM EST | Sat, 12/26/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Detroit Red Wings at Buffalo Sabres Mon, 12/28/2026 7:00 PM EST | Mon, 12/28/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Winnipeg Jets at Buffalo Sabres Mon, 01/04/2027 7:30 PM EST | Mon, 01/04/2027 7:30 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Carolina Hurricanes at Buffalo Sabres Sat, 01/09/2027 7:00 PM EST | Sat, 01/09/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Colorado Avalanche at Buffalo Sabres Thu, 01/14/2027 7:00 PM EST | Thu, 01/14/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Nashville Predators at Buffalo Sabres Sat, 01/16/2027 7:00 PM EST | Sat, 01/16/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Seattle Kraken at Buffalo Sabres Thu, 01/21/2027 7:00 PM EST | Thu, 01/21/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| New York Islanders at Buffalo Sabres Wed, 02/03/2027 7:00 PM EST | Wed, 02/03/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Toronto Maple Leafs at Buffalo Sabres Sat, 02/27/2027 7:00 PM EST | Sat, 02/27/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| St. Louis Blues at Buffalo Sabres Thu, 03/04/2027 7:00 PM EST | Thu, 03/04/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Vancouver Canucks at Buffalo Sabres Tue, 03/09/2027 7:00 PM EST | Tue, 03/09/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| San Jose Sharks at Buffalo Sabres Mon, 03/15/2027 7:00 PM EDT | Mon, 03/15/2027 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Washington Capitals at Buffalo Sabres Thu, 03/18/2027 7:00 PM EDT | Thu, 03/18/2027 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Boston Bruins at Buffalo Sabres Thu, 04/01/2027 7:30 PM EDT | Thu, 04/01/2027 7:30 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
