| Minnesota Twins at Boston Red Sox Fri, 05/22/2026 7:10 PM EDT | Fri, 05/22/2026 7:10 PM EDT | Boston Red Sox | Fenway Park | Boston | Flat | - |
| Minnesota Twins at Boston Red Sox Fri, 05/22/2026 7:10 PM EDT | Fri, 05/22/2026 7:10 PM EDT | Boston Red Sox | Fenway Park | Boston | Flat | - |
| Minnesota Twins at Boston Red Sox Sat, 05/23/2026 4:10 PM EDT | Sat, 05/23/2026 4:10 PM EDT | Boston Red Sox | Fenway Park | Boston | Flat | - |
| Minnesota Twins at Boston Red Sox Sat, 05/23/2026 4:10 PM EDT | Sat, 05/23/2026 4:10 PM EDT | Boston Red Sox | Fenway Park | Boston | Flat | - |
| Minnesota Twins at Boston Red Sox Sun, 05/24/2026 1:35 PM EDT | Sun, 05/24/2026 1:35 PM EDT | Boston Red Sox | Fenway Park | Boston | Flat | - |
| Minnesota Twins at Boston Red Sox Sun, 05/24/2026 1:35 PM EDT | Sun, 05/24/2026 1:35 PM EDT | Boston Red Sox | Fenway Park | Boston | Flat | - |
| Minnesota Twins at Chicago White Sox Mon, 05/25/2026 1:10 PM CDT | Mon, 05/25/2026 1:10 PM CDT | Chicago White Sox | Guaranteed Rate Field | Chicago | Flat | - |
| Minnesota Twins at Chicago White Sox Tue, 05/26/2026 6:40 PM CDT | Tue, 05/26/2026 6:40 PM CDT | Chicago White Sox | Guaranteed Rate Field | Chicago | Flat | - |
| Minnesota Twins at Chicago White Sox Wed, 05/27/2026 6:40 PM CDT | Wed, 05/27/2026 6:40 PM CDT | Chicago White Sox | Guaranteed Rate Field | Chicago | Flat | - |
| Minnesota Twins at Chicago White Sox Wed, 05/27/2026 6:40 PM CDT | Wed, 05/27/2026 6:40 PM CDT | Chicago White Sox | Guaranteed Rate Field | Chicago | Flat | - |
| Minnesota Twins at Chicago White Sox Thu, 05/28/2026 1:10 PM CDT | Thu, 05/28/2026 1:10 PM CDT | Chicago White Sox | Guaranteed Rate Field | Chicago | Flat | - |
| Minnesota Twins at Chicago White Sox Thu, 05/28/2026 1:10 PM CDT | Thu, 05/28/2026 1:10 PM CDT | Chicago White Sox | Guaranteed Rate Field | Chicago | Flat | - |
| Minnesota Twins at Pittsburgh Pirates Fri, 05/29/2026 6:40 PM EDT | Fri, 05/29/2026 6:40 PM EDT | Pittsburgh Pirates | PNC Park | Pittsburgh | Flat | - |
| Minnesota Twins at Pittsburgh Pirates Fri, 05/29/2026 6:45 PM EDT | Fri, 05/29/2026 6:45 PM EDT | Pittsburgh Pirates | PNC Park | Pittsburgh | Flat | - |
| Minnesota Twins at Pittsburgh Pirates Sat, 05/30/2026 4:05 PM EDT | Sat, 05/30/2026 4:05 PM EDT | Pittsburgh Pirates | PNC Park | Pittsburgh | Flat | - |
| Minnesota Twins at Pittsburgh Pirates Sat, 05/30/2026 4:05 PM EDT | Sat, 05/30/2026 4:05 PM EDT | Pittsburgh Pirates | PNC Park | Pittsburgh | Flat | - |
| Minnesota Twins at Pittsburgh Pirates Sun, 05/31/2026 1:35 PM EDT | Sun, 05/31/2026 1:35 PM EDT | Pittsburgh Pirates | PNC Park | Pittsburgh | Flat | - |
| Minnesota Twins at Pittsburgh Pirates Sun, 05/31/2026 1:35 PM EDT | Sun, 05/31/2026 1:35 PM EDT | Pittsburgh Pirates | PNC Park | Pittsburgh | Flat | - |
| Chicago White Sox at Minnesota Twins Mon, 06/01/2026 6:40 PM CDT | Mon, 06/01/2026 6:40 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Chicago White Sox at Minnesota Twins Tue, 06/02/2026 6:40 PM CDT | Tue, 06/02/2026 6:40 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Chicago White Sox at Minnesota Twins Wed, 06/03/2026 12:40 PM CDT | Wed, 06/03/2026 12:40 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Kansas City Royals at Minnesota Twins Thu, 06/04/2026 6:40 PM CDT | Thu, 06/04/2026 6:40 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Kansas City Royals at Minnesota Twins Fri, 06/05/2026 7:15 PM CDT | Fri, 06/05/2026 7:15 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Kansas City Royals at Minnesota Twins Sat, 06/06/2026 1:10 PM CDT | Sat, 06/06/2026 1:10 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Kansas City Royals at Minnesota Twins Sun, 06/07/2026 1:10 PM CDT | Sun, 06/07/2026 1:10 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Minnesota Twins at Detroit Tigers Tue, 06/09/2026 5:40 PM EDT | Tue, 06/09/2026 5:40 PM EDT | Detroit Tigers | Comerica Park | Detroit | Flat | - |
| Minnesota Twins at Detroit Tigers Wed, 06/10/2026 5:40 PM EDT | Wed, 06/10/2026 5:40 PM EDT | Detroit Tigers | Comerica Park | Detroit | Flat | - |
| Minnesota Twins at Detroit Tigers Thu, 06/11/2026 12:10 PM EDT | Thu, 06/11/2026 12:10 PM EDT | Detroit Tigers | Comerica Park | Detroit | Flat | - |
| St. Louis Cardinals at Minnesota Twins Fri, 06/12/2026 7:10 PM CDT | Fri, 06/12/2026 7:10 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| St. Louis Cardinals at Minnesota Twins Sat, 06/13/2026 1:10 PM CDT | Sat, 06/13/2026 1:10 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| St. Louis Cardinals at Minnesota Twins Sun, 06/14/2026 1:10 PM CDT | Sun, 06/14/2026 1:10 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Minnesota Twins at Texas Rangers Mon, 06/15/2026 7:05 PM CDT | Mon, 06/15/2026 7:05 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
| Minnesota Twins at Texas Rangers Mon, 06/15/2026 7:05 PM CDT | Mon, 06/15/2026 7:05 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
| Minnesota Twins at Texas Rangers Tue, 06/16/2026 7:05 PM CDT | Tue, 06/16/2026 7:05 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
| Minnesota Twins at Texas Rangers Tue, 06/16/2026 7:05 PM CDT | Tue, 06/16/2026 7:05 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
| Minnesota Twins at Texas Rangers Thu, 06/18/2026 12:35 PM CDT | Thu, 06/18/2026 12:35 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
| Minnesota Twins at Texas Rangers Thu, 06/18/2026 1:35 PM CDT | Thu, 06/18/2026 1:35 PM CDT | Texas Rangers | Globe Life Field | Arlington | Flat | - |
| Minnesota Twins at Arizona Diamondbacks Fri, 06/19/2026 6:40 PM MST | Fri, 06/19/2026 6:40 PM MST | Arizona Diamondbacks | Chase Field | Phoenix | Flat | - |
| Minnesota Twins at Arizona Diamondbacks Fri, 06/19/2026 6:45 PM MST | Fri, 06/19/2026 6:45 PM MST | Arizona Diamondbacks | Chase Field | Phoenix | Flat | - |
| Minnesota Twins at Arizona Diamondbacks Sat, 06/20/2026 7:10 PM MST | Sat, 06/20/2026 7:10 PM MST | Arizona Diamondbacks | Chase Field | Phoenix | Flat | - |
| Minnesota Twins at Arizona Diamondbacks Sat, 06/20/2026 7:10 PM MST | Sat, 06/20/2026 7:10 PM MST | Arizona Diamondbacks | Chase Field | Phoenix | Flat | - |
| Minnesota Twins at Arizona Diamondbacks Sun, 06/21/2026 12:15 PM MST | Sun, 06/21/2026 12:15 PM MST | Arizona Diamondbacks | Chase Field | Phoenix | Flat | - |
| Minnesota Twins at Arizona Diamondbacks Sun, 06/21/2026 1:10 PM MST | Sun, 06/21/2026 1:10 PM MST | Arizona Diamondbacks | Chase Field | Phoenix | Flat | - |
| Los Angeles Dodgers at Minnesota Twins Mon, 06/22/2026 6:40 PM CDT | Mon, 06/22/2026 6:40 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Los Angeles Dodgers at Minnesota Twins Tue, 06/23/2026 6:40 PM CDT | Tue, 06/23/2026 6:40 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Los Angeles Dodgers at Minnesota Twins Wed, 06/24/2026 6:40 PM CDT | Wed, 06/24/2026 6:40 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Colorado Rockies at Minnesota Twins Fri, 06/26/2026 7:10 PM CDT | Fri, 06/26/2026 7:10 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Colorado Rockies at Minnesota Twins Sat, 06/27/2026 6:10 PM CDT | Sat, 06/27/2026 6:10 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Colorado Rockies at Minnesota Twins Sun, 06/28/2026 1:10 PM CDT | Sun, 06/28/2026 1:10 PM CDT | Minnesota Twins | Target Field | Minneapolis | Flat | - |
| Minnesota Twins at Houston Astros Mon, 06/29/2026 7:10 PM CDT | Mon, 06/29/2026 7:10 PM CDT | Houston Astros | Minute Maid Park | Houston | Flat | - |
