| NHL Preseason - Buffalo Sabres at Pittsburgh Penguins Mon, 09/21/2026 7:00 PM EDT | Mon, 09/21/2026 7:00 PM EDT | Pittsburgh Penguins | PPG Paints Arena | Pittsburgh | Flat | - |
| NHL Preseason - Columbus Blue Jackets at Buffalo Sabres Tue, 09/22/2026 7:00 PM EDT | Tue, 09/22/2026 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| NHL Preseason - Buffalo Sabres at Detroit Red Wings Thu, 09/24/2026 7:00 PM EDT | Thu, 09/24/2026 7:00 PM EDT | Detroit Red Wings | Little Caesars Arena | Detroit | Flat | - |
| NHL Preseason - Pittsburgh Penguins at Buffalo Sabres Sat, 09/26/2026 3:00 PM EDT | Sat, 09/26/2026 3:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Buffalo Sabres at Columbus Blue Jackets (Home Opener) Thu, 10/01/2026 7:00 PM EDT | Thu, 10/01/2026 7:00 PM EDT | Columbus Blue Jackets | Nationwide Arena | Columbus | Flat | - |
| Chicago Blackhawks at Buffalo Sabres (Home Opener) Sat, 10/03/2026 7:00 PM EDT | Sat, 10/03/2026 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Chicago Blackhawks at Buffalo Sabres Sat, 10/03/2026 7:00 PM EDT | Sat, 10/03/2026 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Minnesota Wild at Buffalo Sabres Tue, 10/06/2026 8:00 PM EDT | Tue, 10/06/2026 8:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Dallas Stars at Buffalo Sabres Thu, 10/08/2026 7:00 PM EDT | Thu, 10/08/2026 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Utah Mammoth at Buffalo Sabres Sat, 10/10/2026 7:00 PM EDT | Sat, 10/10/2026 7:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Florida Panthers at Buffalo Sabres Mon, 10/12/2026 1:00 PM EDT | Mon, 10/12/2026 1:00 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Buffalo Sabres At Montreal Canadiens Tue, 10/13/2026 6:30 PM EDT | Tue, 10/13/2026 6:30 PM EDT | Montreal Canadiens | Centre Bell | Montreal | Flat | - |
| Buffalo Sabres at Toronto Maple Leafs Thu, 10/15/2026 6:00 PM EDT | Thu, 10/15/2026 6:00 PM EDT | Toronto Maple Leafs | Scotiabank Arena | Toronto | Flat | - |
| Philadelphia Flyers at Buffalo Sabres Wed, 10/21/2026 7:30 PM EDT | Wed, 10/21/2026 7:30 PM EDT | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Buffalo Sabres at Washington Capitals Sat, 10/24/2026 7:00 PM EDT | Sat, 10/24/2026 7:00 PM EDT | Washington Capitals | Capital One Arena | Washington | Flat | - |
| Buffalo Sabres at San Jose Sharks Tue, 10/27/2026 7:30 PM PDT | Tue, 10/27/2026 7:30 PM PDT | San Jose Sharks | SAP Center at San Jose | San Jose | Flat | - |
| Buffalo Sabres at Anaheim Ducks Thu, 10/29/2026 7:00 PM PDT | Thu, 10/29/2026 7:00 PM PDT | Anaheim Ducks | Honda Center | Anaheim | Flat | - |
| Buffalo Sabres at Los Angeles Kings Sat, 10/31/2026 1:00 PM PDT | Sat, 10/31/2026 1:00 PM PDT | Los Angeles Kings | Crypto.com Arena | Los Angeles | Flat | - |
| Ottawa Senators at Buffalo Sabres Wed, 11/04/2026 7:30 PM EST | Wed, 11/04/2026 7:30 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Columbus Blue Jackets at Buffalo Sabres Fri, 11/06/2026 7:00 PM EST | Fri, 11/06/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Vegas Golden Knights at Buffalo Sabres Sun, 11/08/2026 3:30 PM EST | Sun, 11/08/2026 3:30 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Tampa Bay Lightning at Buffalo Sabres Wed, 11/11/2026 7:30 PM EST | Wed, 11/11/2026 7:30 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Buffalo Sabres at Chicago Blackhawks Thu, 11/12/2026 7:00 PM CST | Thu, 11/12/2026 7:00 PM CST | Chicago Blackhawks | United Center | Chicago | Flat | - |
| Buffalo Sabres at Dallas Stars Sat, 11/14/2026 7:00 PM CST | Sat, 11/14/2026 7:00 PM CST | Dallas Stars | American Airlines Center | Dallas | Flat | - |
| Buffalo Sabres at Philadelphia Flyers Tue, 11/17/2026 7:00 PM EST | Tue, 11/17/2026 7:00 PM EST | Philadelphia Flyers | Wells Fargo Center - PA | Philadelphia | Flat | - |
| Buffalo Sabres at Florida Panthers Sat, 11/21/2026 6:00 PM EST | Sat, 11/21/2026 6:00 PM EST | Florida Panthers | Amerant Bank Arena | Sunrise | Flat | - |
| Buffalo Sabres at Tampa Bay Lightning Sun, 11/22/2026 5:00 PM EST | Sun, 11/22/2026 5:00 PM EST | Tampa Bay Lightning | Amalie Arena | Tampa | Flat | - |
| New York Rangers at Buffalo Sabres Wed, 11/25/2026 7:00 PM EST | Wed, 11/25/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Pittsburgh Penguins at Buffalo Sabres Fri, 11/27/2026 8:00 PM EST | Fri, 11/27/2026 8:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Buffalo Sabres at Edmonton Oilers Tue, 12/01/2026 5:00 PM MST | Tue, 12/01/2026 5:00 PM MST | Edmonton Oilers | Rogers Place | Edmonton | Flat | - |
| Buffalo Sabres at Calgary Flames Thu, 12/03/2026 6:00 PM MST | Thu, 12/03/2026 6:00 PM MST | Calgary Flames | Scotiabank Saddledome | Calgary | Flat | - |
| Buffalo Sabres at Vancouver Canucks Fri, 12/04/2026 6:00 PM PST | Fri, 12/04/2026 6:00 PM PST | Vancouver Canucks | Rogers Arena | Vancouver | Flat | - |
| Buffalo Sabres at Seattle Kraken Sun, 12/06/2026 5:00 PM PST | Sun, 12/06/2026 5:00 PM PST | Seattle Kraken | Climate Pledge Arena | Seattle | Flat | - |
| Edmonton Oilers at Buffalo Sabres Thu, 12/10/2026 7:00 PM EST | Thu, 12/10/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Anaheim Ducks at Buffalo Sabres Sat, 12/12/2026 7:00 PM EST | Sat, 12/12/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Buffalo Sabres at Ottawa Senators Mon, 12/14/2026 1:00 PM EST | Mon, 12/14/2026 1:00 PM EST | Ottawa Senators | Canadian Tire Centre | Kanata | Flat | - |
| Calgary Flames at Buffalo Sabres Tue, 12/15/2026 7:00 PM EST | Tue, 12/15/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Montreal Canadiens at Buffalo Sabres Fri, 12/18/2026 7:00 PM EST | Fri, 12/18/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Los Angeles Kings at Buffalo Sabres Sun, 12/20/2026 6:00 PM EST | Sun, 12/20/2026 6:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Buffalo Sabres at Pittsburgh Penguins Tue, 12/22/2026 7:00 PM EST | Tue, 12/22/2026 7:00 PM EST | Pittsburgh Penguins | PPG Paints Arena | Pittsburgh | Flat | - |
| New Jersey Devils at Buffalo Sabres Sat, 12/26/2026 7:00 PM EST | Sat, 12/26/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Detroit Red Wings at Buffalo Sabres Mon, 12/28/2026 7:00 PM EST | Mon, 12/28/2026 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Winnipeg Jets at Buffalo Sabres Mon, 01/04/2027 7:30 PM EST | Mon, 01/04/2027 7:30 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Buffalo Sabres at Boston Bruins Tue, 01/05/2027 7:30 PM EST | Tue, 01/05/2027 7:30 PM EST | Boston Bruins | TD Garden | Boston | Flat | - |
| Buffalo Sabres at Columbus Blue Jackets Fri, 01/08/2027 7:00 PM EST | Fri, 01/08/2027 7:00 PM EST | Columbus Blue Jackets | Nationwide Arena | Columbus | Flat | - |
| Carolina Hurricanes at Buffalo Sabres Sat, 01/09/2027 7:00 PM EST | Sat, 01/09/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Colorado Avalanche at Buffalo Sabres Thu, 01/14/2027 7:00 PM EST | Thu, 01/14/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Nashville Predators at Buffalo Sabres Sat, 01/16/2027 7:00 PM EST | Sat, 01/16/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
| Buffalo Sabres at New York Islanders Wed, 01/20/2027 7:00 PM EST | Wed, 01/20/2027 7:00 PM EST | New York Islanders | UBS Arena | Elmont | Flat | - |
| Seattle Kraken at Buffalo Sabres Thu, 01/21/2027 7:00 PM EST | Thu, 01/21/2027 7:00 PM EST | Buffalo Sabres | KeyBank Center | Buffalo | Flat | - |
